Tilkomay is an antimicrobial and anti-inflammatory tilmicosin and ketoprofen solution for injection. Tilkomay is indicated for the treatment of bovine respiratory syndrome (BRS) associated with pyrexia caused by tilmicosin-susceptible Mannheimia haemolytica.
Cattle
What is tilmicosin?
Tilmicosin (TMS) is a macrolide antibiotic, synthesized from tylosin. It shows good activity against Gram-positive microorganisms and significant activity against certain Gram-negative bacteria and mycoplasmas. Tilmicosin, like all macrolides, is bacteriostatic, but can be bactericidal at higher concentrations and with certain microorganisms.
Its pharmacokinetic/pharmacodynamic behavior (concentration dependent antibacterial action, fat soluble, high tissue distribution, penetration and intracellular accumulation), yields great advantages in a single dose and makes it the therapeutic tool of choice to treat bacterial infections in the lungs, eyes and feet.
Combination of antibiotic + anti-inflammatory
The combination of antibiotics and anti-inflammatories is considered the therapy of choice for BRD. Macrolides, given their intrinsic properties and ability to reach therapeutic concentrations in the respiratory system, are the most commonly used antibiotics to treat BRD. Tilmicosin is one of the antibiotics in this family with the best results in treating complex respiratory infections like BRD.
Ketoprofen (given its anti-inflammatory, antipyretic and analgesic effects) administered with the antibiotic speeds healing and boosts recovery rates.
The combination of tilmicosin and ketoprofen in one drug administered subcutaneously has been proven to boost the efficacy of both active ingredients compared to being administered separately, increasing the recovery rate and reducing recovery time for sick animals.
Administering tilmicosin and ketoprofen to animals with signs of the disease has been proven effective and reduces the treatment needed, optimizing costs.
TILMICOSIN LUNG AFFINITY
The lung pharmacokinetics study confirmed that Tilmicosin is distributed quickly and evenly and has organ affinity with lung tissue, where it has a long lasting effect. Cmax= 7199.7 μg/kg.
GREATER ANTIPYRETIC EFFECT
The clinical score and antipyretic effects of the group treated with Tilkomay vs the group treated with Tilmicosin and Ketoprofen separately were significantly better at D1 and D2 post-administration, fostering better recovery.
Advantages of Tilkomay
01
Single dose
Treatment with one subcutaneous injection, less to handle.
02
Polypropylene vial
Less risk of breakage.
03
Subcutaneous injection
In more serious cases, animals won’t eat feed and so they can’t be given oral medications.
04
Strong antipyretic effect
Brings down fever quickly and helps the animal recover faster.
05
Fast acting
Peak plasma concentration for tilmicosin is reached from 40 minutes.
06
Fast, even distribution through lung tissue
Tilmicosin is distributed quickly and uniformly and has organ affinity with lung tissue.
Responsible use of antibiotics
Veterinary medications, including antibiotics, play a key role in managing animal health. Farmers, veterinarians and anyone involved in animal care have the responsibility to look out for their health and wellbeing, which requires access to the right tools to do so. We must promote responsible use of antibiotics to treat bacterial infections in livestock and pets. Responsible use means administering precise doses for the period indicated, only when necessary and always with a prescription from a veterinarian.
Proper management of veterinary drugs is part of a comprehensive approach geared towards minimizing diseases, which includes measures like: farm biosecurity, proper facilities, optimal hygiene, balanced nutrition, regular monitoring of animal health and wellbeing, including vaccination when necessary, and a comprehensive healthcare plan.
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BIBLIOGRAPHY
Mestorino N. & Errecalde L.C. (2004) Tilmicosina: un nuevo antibiótico macrólido de uso veterinario. Analecta Veterinaria, 24(2): 21-28.
